A rise in Treasury bond yields and mixed retail results weighed on Wall Street stocks early Wednesday.
There remains a strong expectation that the Federal Reserve will raise interest rates in the near future, with investors closely monitoring the 10-year US Treasury note, which has moved closer to the four percent mark.
Neel Kashkari, president of the Minneapolis Fed, said in remarks on Wednesday that he is open to a quarter or half-point increase in interest rates at the next meeting of the central bank.
The market has been concerned that the US economy is running hotter than policymakers expect, which could mean that interest rates may remain higher for a longer period than expected.
Adam Sarhan, president of 50 Park Investments, has expressed concern that the Fed could overshoot its target and see interest rates rise too much, which could cause a recession.
At 32,678.47, the Dow Jones Industrial Average was up 0.1 percent at about 20 minutes into trading.
Nasdaq Composite Index gained 0.1 percent at 11,460.72, while the broad-based S&P 500 dropped 0.1 percent to 3,966.41.
A price drop of 2.6 percent was reported by home improvement retailer Lowe's after it reported lower comparable sales for the fourth quarter, while a price rise of 3.6 percent was reported by department store Kohl's after it reported a $273 million loss.
Vaccine manufacturer Novavax has plunged 24.1 percent after admitting that "substantial doubt exists" about its ability to continue to operate as a going concern after acknowledging that "substantial doubt exists.".
After being hit by manufacturing and regulatory delays, the company fell behind in the race for a global vaccine, which was once a frontrunner.
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